The objective of the present investigation was to design floating tablets of famotidine. A full 23 factorial design was adopted using hydroxy propyl methylcellulose, sodium bicarbonate and ethyl cellulose as independent variables for the preparation of the famotidine tablets. The prepared floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and drug release study. Multiple regression analysis was performed for dependent variables floating lag time, percent of drug release with in 1h (Q1), 10h (Q10) and diffusion exponent (n). Polynomial equations and response surface plots were generated for all dependent variables. It was observed that all the factors had significant contribution on all dependent variables studied. The study of analysis of variance revealed that floating lag time was primarily influenced by concentration of sodium bicarbonate. The release of famotidine was influenced by concentration of hydroxy propyl methylcellulose and ethyl cellulose.
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